主动脉瓣狭窄AorticValveSte

Valvularadj.瓣膜的\?val-vy?-l?r\

风心病杂音

Octogenariann.八旬人

\??k-t?-j?-?ner-ē-?n\

Valvularaorticstenosisisaprogressivediseaseinwhichtheendstageischaracterizedbyobstructionofleftventricularoutflow,resultingininadequatecardiacoutput,decreasedexercisecapacity,heartfailure,anddeathfromcardiovascularcauses.Theprevalenceofaorticstenosisisonlyabout0.2%amongadultsbetweentheagesof50and59yearsbutincreasesto9.8%inoctogenarians,withanoverallprevalenceof2.8%inadultsolderthan75yearsofage.1

瓣膜性主动脉狭窄是一种进行性疾病，疾病终末期的特征有左室流出道梗阻而导致心输出量不足、运动耐量下降、心力衰竭和心源性死亡。主动脉瓣狭窄的患病率在50-59岁人群中仅为0.2%，而80-89岁人群中的患病率升高至9.8%，75岁以上人群的总体患病率为2.8%。

1.常用医学词组

valvularaorticstenosis瓣膜性主动脉狭窄

cardiacoutput心输出量

心衰之呼吸困难

房颤AtrialFibrillation

exercisecapacity运动耐量

生物瓣膜置换术

Althoughmortalityisnotincreasedwhenaorticstenosisisasymptomatic,therateofdeathismorethan50%at2yearsforpatientswithsymptomaticdiseaseunlessaortic-valvereplacementisperformedpromptly.Atotalof65,aortic-valvereplacementswereperformedintheUnitedStatesin,primarilyforaorticstenosis;70%oftheseprocedureswereperformedinpatientsolderthan65yearsofage,contributingtothehighcostofhealthcareinouragingpopulation.Currently,therearenomedicaltherapiestopreventorslowtheprogressionofthedisease.Instead,improvingpatientout







































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